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SKIN SCIENCE

Retinol Side Effects and How to Reduce Skin Irritation

Retinoids may feel like a modern skincare obsession, but they have been around far longer than most people realise. First discovered in 1909 and used in skincare by the 1950s, this family of vitamin A ingredients has a long history of helping skin look clearer, smoother and more refined.

Dermatologists originally relied on retinoic acid, the strongest form of vitamin A, to treat spots because it helped reduce inflammation and clear out pores. As research grew, so did its reputation. By the 1980s, retinoids were being used to target the visible signs of ageing, like fine lines, wrinkles and uneven tone.

By the 1990s, however, retinoic acid had developed a reputation for being highly effective but also quite intense. It delivered results, but often with a side of irritation. That is when a gentler option started to gain popularity.

Enter retinol. A milder, non-prescription version of retinoic acid, retinol offers many of the same visible benefits without the strength. Even so, it still has a reputation for being “too much” for some skin types. Questions like “Will it sting?” or “Will I peel?” are still incredibly common.

Thankfully, formulas have come a long way. With the right balance of supportive ingredients, you can enjoy the benefits of retinol without the typical side effects.

The Secret Formula: Retinol + Beta-Carotene + Coenzyme Q10

Retinol is gentler than retinoic acid, but it can still cause dryness or redness for some. That is why choosing a formula that pairs retinol with calming and protective ingredients makes all the difference.

Beta-carotene, also known as provitamin A, helps support and stabilise retinol. This allows the skin to enjoy the benefits with less chance of discomfort. It also helps improve the look of redness, uneven tone and dullness by defending against oxidative stress.

Coenzyme Q10 (CoQ10) is another ingredient that works beautifully alongside retinol. As a powerful antioxidant, it helps protect against free radicals, which can contribute to premature ageing.

Together, retinol, beta-carotene and CoQ10 complement one another. Retinol helps CoQ10 absorb more effectively, while CoQ10 helps soften any potential side effects from the retinol. The result is a balanced and intelligent trio that supports visible results while helping the skin feel more comfortable.

Why Triple Retinol Renewal Really Works

This combination of ingredients powers our High Potency Triple Retinol Renewal Serum and High Potency Triple Retinol Renewal Eye Serum. 

Both formulas have been clinically tested in the UK and are proven to deliver visible results while remaining gentle enough for most skin types. 

In a user trial with 102 women over 28 days: 

  • 83 percent said the face serum smoothed skin and restored radiance 
  • 91 percent said it felt gentle to use 
In another trial with 34 women:
  • 91 percent noticed a visible reduction in dark circles after using the eye serum for eight weeks

The secret lies in the triple retinol blend. Encapsulated retinol, retinol ester and phyto-retinol work together to gently support cell turnover for skin that looks firmer, fresher and more youthful. 

At the same time, beta-carotene and CoQ10 help keep the formula balanced and comfortable, reducing the risk of irritation. 

If you want all the benefits of retinol without the worry that often comes with it, this kind of formulation makes it possible. You can enjoy smoother, brighter, healthier-looking skin without unnecessary discomfort. 

Perricone MD
Perricone MD Writer and expert

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