The Science

Dr. Perricone discusses the ultimate
firming ingredient, DMAE.


DMAE, a nutrient near and dear to my heart (and brain and skin, as well) or dimethylaminoethenol, is a naturally occurring substance with significant anti- inflammatory, anti-aging properties. DMAE is found in sardines and anchovies, and small amounts of it are also produced naturally in the human brain. DMAE can also be taken as a nutritional supplement and applied topically to the skin. All three methods work synergistically for optimum effect.


Let's start with diet. Only one food has the reputation from time immemorial of being a "brain food." That food is fish, especially fish that is high in DMAE. DMAE is known as a cognitive enhancer. A diet high in DMAE will enable you to think more clearly, have an improved memory, and a much greater problem solving ability. DMAE is a building block of the neurotransmitter acetylcholine. Like other neurotransmitters acetylcholine allows one nerve to communicate with another or for a nerve to communicate with a muscle. Studies have also shown that DMAE acts as an antioxidant by stabilising cell membranes, protecting them from free radical damage. By raising levels of DMAE in our bodies, we can think more clearly and have greater muscle tone in both face and body.


Numerous studies have shown that topical application of DMAE increases the appearance of firmness, tone and lift to the skin. DMAE also improves the appearance of skin elasticity and luminosity, helping to decrease the look of lines and wrinkles while brightening skin and evening out imperfections. Many scientists and researchers in the field of dermatology are studying this remarkable nutrient, and their exciting findings validate what I have known for decades: DMAE has a unique, important role as a safe and effective strategy to help delay or reverse the appearance of aging skin.