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Essential Fx Acyl-Glutathione Deep Crease Serum

An intense, moisturising serum with a blend of vitamin F for deep lines and wrinkles, including the corner of the mouth, frown lines and smile lines.

GBP 138.0



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Customer Reviews

Overall Rating : 3.93 / 5 (68 Reviews)
  • 38 5 star reviews
  • 9 4 star reviews
  • 8 3 star reviews
  • 4 2 star reviews
  • 9 1 star reviews
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Top Customer Reviews

Where reviews refer to foods or cosmetic products, results may vary from person to person. Customer reviews are independent and do not represent the views of The Hut Group.


Been using this for one week and already see huge improvement to lines on my forehead. Lovely smell and texture and makes my skin feel great. Im quite new to Perricone products but they really are boosting my self esteem and transforming my skin. I tell everyone to use it!

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Great product

I do love this serum. It definitely makes a difference; one of the only products that helps with marionette lines. It is a bit too expensive for me. I ordered it when I got a good discount ( 1/2 off). I don't think I'll be ordering it again until that discount as available again because I cannot afford it.

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Reliable Product

Perricone MD always provides Great products that are Very Reliable. The Deep Crease Serum has worked wonders on what used to be "deep creases" on my face! The key is to use it Daily! Works Great!

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I am so impressed with this deep crease serum, for me, it exceeded my hopes and expectations. I have been forming fine lines across my forehead from repetitive motions and stress!) and have been watching them grow deeper and spread further over time. I have tried other products with mild results, but this is the first serum that I have ever used where I can say that I actually see a significant difference in my skin. For the past month I have incorporated this serum every night as part of my PM skincare routine and the lines are not only fading, but some have actually disappeared... this stuff is magic! At first I only was using two drops on my forehead, but now I also use a drop on my smile lines and across the horizontal lines on my neck. I am so incredibly pleased with my results so far, I look forward to continued improvement of my skin with daily use. The price may be steep, but you truly use so little at a time and the results are noticeable and very real.

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Small reduction

Used over the past month, twice a day. Small reduction in my major forehead creases.

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The best serum ever

You would look at women posting their before and after pics and wonder about the depth of their facial creases, their age, life style, nutrition as a factors influencing wrinkles formation and leave the web site in disbelieve I am asking you to believe me cause:I am 62, watching what I am eating, working my sweat by gardening and walking, taking my supplements.Never developed habit of using the sun screamDeveloped deep creases or so cold smile wrinkles long time ago. I thought it was it.Bought the first Dr Perricone book 3 years ago and started using his cream and serum 3 years ago1 year Ago he came up with the new line of Fox essential glutathione eye and deep creases cerium, creams and so onStarted using his deep crease Fx glutathione in January not even twice per day, just at night timeI am telling the truth: my absolutely deep crease on the left side disappeared completely in April and the left side became much superficial by nowI LOVE Dr Perricone and what he does for female not only beauty but self esteem and moodHe definitely knows what woman wants 

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Love This Cream!

Got it in a kit! I completely changed over my skincare products from another company to Perricone MD after they allowed afterpay and klarna. I have been wanting to for awhile but couldn't afford the money all at once. Now I can. I got one half ounce with two other products. Been using for about a month. I only use it on my lines and wrinkles. Not my full face. For me, it works. On my forehead, and all around my mouth the lines are going away! When I run out, will buy the full size. This is the only skincare I have ever used that actually does what it says it's going to do! I've had good skincare,just not as good as this! Won't go back.

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Good name for product

Good product, does seem to help with marionette lines and lip lines.

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Not working

Its been 10 days since I started using it every morning and evening, sometimes more in the afternoon but havent seen any results or improvement on my skin. I have a shallow wrinkle alongside my mouth and the serum doesnt fade it. With that price, I expected it works after few days of using as I know my skin well, If anything works on my skin, i will see results immediately, I mean I can feel it right at the first time I put on my skin, but if I dont feel anything I know nothing is coming. 

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I loved it

The results were immediate.

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