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Acyl-Glutathione 30ml

Product Overview

Dr. Perricone created this breakthrough skincare product to deliver a form of Glutathione directly to the skin. This patent pending formula dramatically reduces the appearance of creases and other signs of skin aging.

What are the benefits?

- Helps to minimize the appearance of lines and creases.
- Visibly improves the look of skin texture.
- Improves the level of moisture leaving skin feeling more supple and resilient.
- Addresses dryness and diminishes the look of enlarged pores.

How does it work?

Through years of anti–aging research, Dr. Perricone identified Glutathione as a "master antioxidant." Using a stable form of this critical nutrient, Dr. Perricone developed a Acyl-Glutathione to help combat the appearance of the signs of aging, such as expression lines, creases and loss of firmness.

How do I apply it?

Dr. Perricone recommends first warming up a small amount of product between your hands to facilitate spread over the entire face. Slide the pads of the fingers from the center of the eyebrows towards the outside of the forehead.

Then with the palms of the hand proceed over temples, cheekbones and sides of nose in a gentle patting motion. End by sweeping upwards from the neck to the chin and jawline. Apply morning and evening after make-up removal on well cleansed skin.

Clinical Results

85% saw a reduction in the appearance of horizontal forehead creases
90% saw a reduction in the appearance of eleven creases
85% saw a reduction in the appearance of smile creases
88% saw a reduction in the appearance of marionette lines
85% saw improvement in how thin, fragile and “papery” skin looked and felt
90% saw improvement in the overall youthfulness of their skin and felt more confident
about their skin

*Based on a 4 week independent consumer-use study.


Aqua (Water), Isopropyl Palmitate, Tetrahexyldecyl Ascorbate, Cetearyl Alcohol, Phosphatidylcholine, S-Palmitoylglutathione, L-Tyrosine, Dimethyl MEA (DMAE), Glyceryl Stearate, PEG-100 Stearate, Ceteareth-20, Glycolic Acid, Oligopeptide-17, Oligopeptide-49, Squalane, Butyrospermum Parkii (Shea) Butter, Limnanthes Alba (Meadowfoam) Seed Oil, Docosahexaenoic Acid, Dimethicone, Sesamum Indicum (Sesame) Seed Oil, Glycerin, Magnesium Aspartate, Zinc Gluconate, Phenoxyethanol, Caprylyl Glycol, Parfum (Fragrance), Propylene Glycol, Disodium EDTA, Hydrolyzed Glycosaminoglycans, Elaeis Guineensis (Palm) Oil, Citric Acid, Tocotrienols, Copper Gluconate, Sorbic Acid, Tocopherol, Ascorbyl Palmitate, Thioctic Acid (Alpha-Lipoic Acid), Linalool

Product's Review

based on 108 reviews


of respondents would recommend this to a friend.

  • Reviewer Profile:
  • Minimalist (1), Beauty Conscious  (1)
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Reviewed by 108 customers

Displaying reviews 1 - 3

(0 of 1 people found this review helpful)

this product is excellent

I was delighted to see this product re-launched. I missed it! I was sat in the barbers today looking in the mirror thinking how improved my skins looks!

It really does improve the overall look of the skin and is so good at reducing wrinkles caused by aging. It's great around the eyes for crows feet and it really helps with improving cheeky firmness. It absorbs into the skin quickly.

The rule might be thinnest to thickest, but I think it works better to apply this first. Wait a few minutes then apply cold plasma. Then a few minutes later apply an SPF.

Even better: other people have noticed it works - under-guessing my age!

For me this really makes a noticeable difference. Great it is back.

Pros: Softens Skin, Lightweight, Moisturizes, Non-Greasy

Bottom line: Yes, I would recommend this to a friend


About me Minimalist

(1 of 2 people found this review helpful)

Fabulous for mature skin

I feel that the Acyl- Glutathione should be better for my mature skin. I am liking it and feeling that my skin's elasticity and firmness has improved


About me Beauty Conscious

(7 of 11 people found this review helpful)

Don't use if you have sensitive skin

I'm 50 and have fair skin with very few wrinkles;however, I have noticed that since I have lost weight I have a lack of firmness around my mouth. I have used the Dr. Perricone's eye C-Ester and firming lotion for the past year and I have liked those. So I thought I would give this product a chance. I've been using it for a week and have developed red, itchy skin, and a couple of bumps. My skin also has a burning sensation. So Dr. Perricone should note that this product should not be used on sensitive skin or on people who have Rosacea.

Cons: Irritates Skin, Skin itches, Skin feels drier

Bottom line: No, I would not recommend this to a friend

from Tallahassee, Florida

About me 

One-time Purchase

In stock

Free Deluxe Sample

You are currently entitled to a complimentary Photo Plasma sachet.

Spend another £80.00 to receive a complimentary Deluxe Sample worth up to £30

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Complete your core regime

These are the three core products that DR Perricone recommends to start off your daily skincare regime.

Enhance your core regime

These are the three products that DR Perricone recommends to enhance your daily skincare regime.

  • 1


  • Acyl-Glutathione


    Learn More
  • 2

    Eye Treatment

  • Cold Plasma Eye

    Cold Plasma Eye

    Learn More
  • 3


  • Cold Plasma

    Cold Plasma

    Learn More
  • 4

    Night Treatment

    Use in the evening to help deliver dramatically brighter, firmer and smoother skin by morning

  • Vitamin C Ester 15

    Vitamin C Ester 15

    Learn More

Beyond the Basics

Dr Perricone has formulated unique targeted treatments to address sun protection with products that bridge the gap between serious skincare and makeup. Additionally, he has designed treatments to complement and support a daily skincare regime.

No Makeup Makeup
No Makeup Skincare
Learn More
Targeted Treatments
Targeted Treatments
Learn More